Published in
American Society of Hematology, Blood Advances, 21(3), p. 3248-3260, 2019
DOI: 10.1182/bloodadvances.2019000703
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Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma
Journal article published in 2019 by
Andrea Schmidts 
,
Maria Ormhøj ,
Bryan D. Choi,
Allison O. Taylor,
Amanda A. Bouffard,
Irene Scarfò ,
Rebecca C. Larson ,
Matthew J. Frigault,
Kathleen Gallagher,
Ana P. Castano,
Lauren S. Riley,
Maria L. Cabral,
Angela C. Boroughs,
Rubí M.-H. Velasco Cárdenas,
Wolfgang Schamel
and other authors.
,
Maria Ormhøj ,
Bryan D. Choi,
Allison O. Taylor,
Amanda A. Bouffard,
Irene Scarfò ,
Rebecca C. Larson ,
Matthew J. Frigault,
Kathleen Gallagher,
Ana P. Castano,
Lauren S. Riley,
Maria L. Cabral,
Angela C. Boroughs,
Rubí M.-H. Velasco Cárdenas,
Wolfgang Schamel
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key PointsA trimeric extracellular moiety of APRIL has enhanced binding to BCMA and TACI compared with monomeric APRIL when incorporated into a CAR. T cells transduced with a trimeric APRIL-based CAR are a promising approach for the treatment of MM.