Published in
American Society of Hematology, Blood Advances, 21(3), p. 3201-3213, 2019
DOI: 10.1182/bloodadvances.2019000641
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Replication timing alterations in leukemia affect clinically relevant chromosome domains
Journal article published in 2019 by
Juan Carlos Rivera-Mulia 
,
Takayo Sasaki,
Claudia Trevilla-Garcia,
Naoto Nakamichi,
David J. H. F. Knapp ,
Colin A. Hammond,
Bill H. Chang ,
Jeffrey W. Tyner,
Meenakshi Devidas ,
Jared Zimmerman,
Kyle N. Klein,
Vivek Somasundaram,
Brian J. Druker ,
Tanja A. Gruber,
Amnon Koren
and other authors.
,
Takayo Sasaki,
Claudia Trevilla-Garcia,
Naoto Nakamichi,
David J. H. F. Knapp ,
Colin A. Hammond,
Bill H. Chang ,
Jeffrey W. Tyner,
Meenakshi Devidas ,
Jared Zimmerman,
Kyle N. Klein,
Vivek Somasundaram,
Brian J. Druker ,
Tanja A. Gruber,
Amnon Koren
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points DNA replication timing of >100 pediatric leukemic samples identified BCP-ALL subtype-specific genome alteration signatures. Comparative analyses identified features of specific stages of B-cell differentiation and potential associations with clinical outcome.