Published in
American Society of Hematology, Blood Advances, 20(3), p. 3111-3122, 2019
DOI: 10.1182/bloodadvances.2019000518
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Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern
Journal article published in 2019 by
Gerbrig Berger,
Mylene Gerritsen 
,
Guoqiang Yi,
Theresia N. Koorenhof-Scheele,
Leonie I. Kroeze ,
Marian Stevens-Kroef ,
Kenichi Yoshida ,
Yuichi Shiraishi,
Eva van den Berg,
Hein Schepers,
Geert Huls,
André B. Mulder,
Seishi Ogawa ,
Joost H. A. Martens ,
Joop H. Jansen
and other authors.
,
Guoqiang Yi,
Theresia N. Koorenhof-Scheele,
Leonie I. Kroeze ,
Marian Stevens-Kroef ,
Kenichi Yoshida ,
Yuichi Shiraishi,
Eva van den Berg,
Hein Schepers,
Geert Huls,
André B. Mulder,
Seishi Ogawa ,
Joost H. A. Martens ,
Joop H. Jansen
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key PointsRing sideroblasts in AML are associated with complex karyotypes and TP53 mutations. Gene expression studies in CD34+ AML cells suggest an altered erythroid differentiation program in AML with ring sideroblasts.