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American Society of Hematology, Blood Advances, 20(3), p. 3038-3051, 2019

DOI: 10.1182/bloodadvances.2019000574

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Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

Journal article published in 2019 by Kaycee B. Moshofsky ORCID, Hyun J. Cho, Guanming Wu ORCID, Kyle A. Romine ORCID, Matthew T. Newman, Yoko Kosaka ORCID, Shannon K. McWeeney, Evan F. Lind
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points MEK inhibition rescues T cells from activation-induced cell death in an AML model. MEK inhibitor sensitivity is associated with inflammation pathways and PD-L1 expression.