Dissemin is shutting down on January 1st, 2025

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American Society of Hematology, Blood, 26(128), p. 3023-3024, 2016

DOI: 10.1182/blood-2016-11-748145

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Releasing the brakes on BTK-targeting miRNA

Journal article published in 2016 by Matthew D. Blunt ORCID, Andrew J. Steele ORCID
Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Abstract

In this issue of Blood, Bottoni et al demonstrate that histone deacetylase (HDAC) inhibition promotes the upregulation of microRNAs (miRNAs or miRs) which target Bruton tyrosine kinase (BTK), subsequently suppressing prosurvival signaling in chronic lymphocytic leukemia (CLL) samples, and highlight a rationale for HDAC inhibitors in combination with ibrutinib to treat patients.1