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American Society of Hematology, Blood Advances, 19(3), p. 2859-2865, 2019

DOI: 10.1182/bloodadvances.2019000053

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Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Journal article published in 2019 by Kate H. Gartlan ORCID, Motoko Koyama, Katie E. Lineburg, Karshing Chang, Kathleen S. Ensbey, Rachel D. Kuns, Andrea S. Henden ORCID, Luke D. Samson, Andrew D. Clouston, Angel F. Lopez, Kelli P. A. MacDonald, Geoffrey R. Hill ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points GM-CSF is derived from both Th17/Tc17-positive and Th17/Tc17-negative donor lineages after bone marrow transplantation. GM-CSF promotes the accumulation of alloantigen-presenting, migratory donor DCs in the gastrointestinal tract during GVHD.