Published in
American Society of Hematology, Blood Advances, 19(3), p. 2866-2869, 2019
DOI: 10.1182/bloodadvances.2019000362
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Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD
Journal article published in 2019 by
Jonathan L. Golob 
,
Martha M. DeMeules,
Tillie Loeffelholz,
Z. Z. Quinn,
Michael K. Dame ,
Sabrina S. Silvestri,
Michael C. Wu ,
Thomas M. Schmidt ,
Tina L. Fiedler,
Matthew J. Hoostal,
Marco Mielcarek,
Jason Spence,
Steven A. Pergam ,
David N. Fredricks
,
Martha M. DeMeules,
Tillie Loeffelholz,
Z. Z. Quinn,
Michael K. Dame ,
Sabrina S. Silvestri,
Michael C. Wu ,
Thomas M. Schmidt ,
Tina L. Fiedler,
Matthew J. Hoostal,
Marco Mielcarek,
Jason Spence,
Steven A. Pergam ,
David N. Fredricks
This paper is made freely available by the publisher.
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Abstract
Key Points The presence of butyrogenic bacteria after the onset of acute GVHD associates with subsequent steroid-refractory GVHD or chronic GVHD. Butyrate inhibits human colonic stem cells from forming an intact epithelial monolayer.