American Association for Cancer Research, Clinical Cancer Research, 2(25), p. 460-462, 2019
DOI: 10.1158/1078-0432.ccr-18-3146
Full text: Unavailable
Abstract The presence of internal tandem duplications (ITD) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis in patients with acute myeloid leukemia. Now, specific structural features of the ITDs are also suggested to alter patient outcome, including sensitivity to targeted therapies, prompting their evaluation in therapeutic algorithms. See related article by Schwartz et al., p. 573