Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Brazel, David M.; Jiang, Yu; Hughey, Jordan M.; Turcot, Valérie; Zhan, Xiaowei; Gong, Jian; Batini, Chiara; Weissenkampen, J. Dylan; Liu, MengZhen; Barnes, Daniel R.; Bertelsen, Sarah; Chou, Yi-Ling; Erzurumluoglu, A. Mesut; Faul, Jessica D.; Haessler, Jeff; Hammerschlag, Anke R.; Hsu, Chris; Kapoor, Manav; Lai, Dongbing; Le, Nhung; de Leeuw, Christiaan A.; Loukola, Anu; Mangino, Massimo; Melbourne, Carl A.; Pistis, Giorgio; Qaiser, Beenish; Rohde, Rebecca; Shao, Yaming; Stringham, Heather; Wetherill, Leah; Zhao, Wei; Agrawal, Arpana; Bierut, Laura; Chen, Chu; Eaton, Charles B.; Goate, Alison; Haiman, Christopher; Heath, Andrew; Iacono, William G.; Martin, Nicholas G.; Polderman, Tinca J.; Reiner, Alex; Rice, John; Schlessinger, David; Scholte, H. Steven; Smith, Jennifer A.; Tardif, Jean-Claude; Tindle, Hilary A.; van der Leij, Andries R.; Boehnke, Michael; Chang-Claude, Jenny; Cucca, Francesco; David, Sean P.; Foroud, Tatiana; Howson, Joanna M. M.; Kardia, Sharon L. R.; Kooperberg, Charles; Laakso, Markku; Lettre, Guillaume; Madden, Pamela; McGue, Matt; North, Kari; Posthuma, Danielle; Spector, Timothy; Stram, Daniel; Tobin, Martin D.; Weir, David R.; Kaprio, Jaakko; Abecasis, Gonçalo R.; Liu, Dajiang J.; Vrieze, Scott; Surendran, Praveen; Young, Robin; Nielsen, Sune Fallgaard; Rasheed, Asif; Samuel, Maria; Kontto, Jukka; Perola, Markus; Caslake, Muriel; de Craen, Anton J. M.; Trompet, Stella; Uria-Nickelsen, Maria; Malarstig, Anders; Reily, Dermot F.; Hoek, Maarten; Vogt, Thomas; Jukema, J. Wouter; Sattar, Naveed; Ford, Ian; Packard, Chris J.; Alam, Dewan S.; Majumder, Abdulla al Shafi; Di Angelantonio, Emanuele; Chowdhury, Rajiv; Amouyel, Philippe; Arveiler, Dominique; Blankenberg, Stefan; Ferrières, Jean; Kee, Frank; Kuulasmaa, Kari; Müller-Nurasyid, Martina; Veronesi, Giovanni; Virtamo, Jarmo; Epic-Cvd Consortium,; Frossard, Philippe; Nordestgaard, Børge Grønne; Saleheen, Danish; Danesh, John; Butterworth, Adam S.; Jackson, Victoria E.; Varga, Tibor V.; Warren, Helen R.; Tragante, Vinicius; Tachmazidou, Ioanna; Harris, Sarah E.; Evangelou, Evangelos; Marten, Jonathan; Zhang, Weihua; Altmaier, Elisabeth; Luan, Jian’an; Langenberg, Claudia; Scott, Robert A.; Yaghootkar, Hanieh; Stirrups, Kathleen; Kanoni, Stavroula; Marouli, Eirini; Karpe, Fredrik; Dominiczak, Anna F.; Sever, Peter; Poulter, Neil; Rolandsson, Olov; Baumbach, Clemens; Afaq, Saima; Chambers, John C.; Kooner, Jaspal S.; Wareham, Nicholas J.; Renström, Frida; Hallmans, Göran; Marioni, Riccardo E.; Corley, Janie; Starr, John M.; Verweij, Niek; de Boer, Rudolf A.; van der Meer, Peter; Yavas, Ersin; Vaartjes, Ilonca; Bots, Michiel L.; Asselbergs, Folkert W.; Grabe, Hans J.; Völzke, Henry; Nauck, Matthias; Weiss, Stefan; Pharoah, Paul D. P.; Dunning, Alison M.; Dennis, Joe G.; Thompson, Deborah J.; Michailidou, Kyriaki; Easton, Douglas F.; Antoniou, Antonis C.; Tyrrell, Jessica; Mihailov, Evelin; Samani, Nilesh J.; Zhou, Kaixin; Neville, Matthew J.; Metspalu, Andres; Palmer, Colin N. A.; Hall, Ian P.; Strachan, David P.; Deary, Ian J.; Frayling, Tim M.; Hayward, Caroline; van der Harst, Pim; Zeggini, Eleftheria; Understanding Society Scientific Group,; Munroe, Patricia B.; Jansson, Jan-Håkan; Franks, Paul W.; Deloukas, Panos; Caulfield, Mark J.; Wain, Louise V.

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David Brazel
Brazel et al., 2019

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Elsevier, Biological Psychiatry, 11(85), p. 946-955, 2019

DOI: 10.1016/j.biopsych.2018.11.024

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@article{Brazel2019,
  author = {Brazel, David M. and Jiang, Yu and Hughey, Jordan M. and Turcot, Valérie and Zhan, Xiaowei and Gong, Jian and Batini, Chiara and Weissenkampen, J. Dylan and Liu, MengZhen and Barnes, Daniel R. and Bertelsen, Sarah and Chou, Yi-Ling and Erzurumluoglu, A. Mesut and Faul, Jessica D. and Haessler, Jeff and Hammerschlag, Anke R. and Hsu, Chris and Kapoor, Manav and Lai, Dongbing and Le, Nhung and de Leeuw, Christiaan A. and Loukola, Anu and Mangino, Massimo and Melbourne, Carl A. and Pistis, Giorgio and Qaiser, Beenish and Rohde, Rebecca and Shao, Yaming and Stringham, Heather and Wetherill, Leah and Zhao, Wei and Agrawal, Arpana and Bierut, Laura and Chen, Chu and Eaton, Charles B. and Goate, Alison and Haiman, Christopher and Heath, Andrew and Iacono, William G. and Martin, Nicholas G. and Polderman, Tinca J. and Reiner, Alex and Rice, John and Schlessinger, David and Scholte, H. Steven and Smith, Jennifer A. and Tardif, Jean-Claude and Tindle, Hilary A. and van der Leij, Andries R. and Boehnke, Michael and Chang-Claude, Jenny and Cucca, Francesco and David, Sean P. and Foroud, Tatiana and Howson, Joanna M. M. and Kardia, Sharon L. R. and Kooperberg, Charles and Laakso, Markku and Lettre, Guillaume and Madden, Pamela and McGue, Matt and North, Kari and Posthuma, Danielle and Spector, Timothy and Stram, Daniel and Tobin, Martin D. and Weir, David R. and Kaprio, Jaakko and Abecasis, Gonçalo R. and Liu, Dajiang J. and Vrieze, Scott and Surendran, Praveen and Young, Robin and Nielsen, Sune Fallgaard and Rasheed, Asif and Samuel, Maria and Kontto, Jukka and Perola, Markus and Caslake, Muriel and de Craen, Anton J. M. and Trompet, Stella and Uria-Nickelsen, Maria and Malarstig, Anders and Reily, Dermot F. and Hoek, Maarten and Vogt, Thomas and Jukema, J. Wouter and Sattar, Naveed and Ford, Ian and Packard, Chris J. and Alam, Dewan S. and Majumder, Abdulla al Shafi and Di Angelantonio, Emanuele and Chowdhury, Rajiv and Amouyel, Philippe and Arveiler, Dominique and Blankenberg, Stefan and Ferrières, Jean and Kee, Frank and Kuulasmaa, Kari and Müller-Nurasyid, Martina and Veronesi, Giovanni and Virtamo, Jarmo and Epic-Cvd Consortium,  and Frossard, Philippe and Nordestgaard, Børge Grønne and Saleheen, Danish and Danesh, John and Butterworth, Adam S. and Jackson, Victoria E. and Varga, Tibor V. and Warren, Helen R. and Tragante, Vinicius and Tachmazidou, Ioanna and Harris, Sarah E. and Evangelou, Evangelos and Marten, Jonathan and Zhang, Weihua and Altmaier, Elisabeth and Luan, Jian’an and Langenberg, Claudia and Scott, Robert A. and Yaghootkar, Hanieh and Stirrups, Kathleen and Kanoni, Stavroula and Marouli, Eirini and Karpe, Fredrik and Dominiczak, Anna F. and Sever, Peter and Poulter, Neil and Rolandsson, Olov and Baumbach, Clemens and Afaq, Saima and Chambers, John C. and Kooner, Jaspal S. and Wareham, Nicholas J. and Renström, Frida and Hallmans, Göran and Marioni, Riccardo E. and Corley, Janie and Starr, John M. and Verweij, Niek and de Boer, Rudolf A. and van der Meer, Peter and Yavas, Ersin and Vaartjes, Ilonca and Bots, Michiel L. and Asselbergs, Folkert W. and Grabe, Hans J. and Völzke, Henry and Nauck, Matthias and Weiss, Stefan and Pharoah, Paul D. P. and Dunning, Alison M. and Dennis, Joe G. and Thompson, Deborah J. and Michailidou, Kyriaki and Easton, Douglas F. and Antoniou, Antonis C. and Tyrrell, Jessica and Mihailov, Evelin and Samani, Nilesh J. and Zhou, Kaixin and Neville, Matthew J. and Metspalu, Andres and Palmer, Colin N. A. and Hall, Ian P. and Strachan, David P. and Deary, Ian J. and Frayling, Tim M. and Hayward, Caroline and van der Harst, Pim and Zeggini, Eleftheria and Understanding Society Scientific Group,  and Munroe, Patricia B. and Jansson, Jan-Håkan and Franks, Paul W. and Deloukas, Panos and Caulfield, Mark J. and Wain, Louise V.},
  doi = {10.1016/j.biopsych.2018.11.024},
  journal = {Biological Psychiatry},
  month = {jun},
  pages = {946-955},
  title = {Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use},
  url = {https://oadoi.org/10.1016/j.biopsych.2018.11.024},
  volume = {85},
  year = {2019}
}

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