Published in
Oxford University Press (OUP), The Journal of Infectious Diseases, 12(220), p. 1962-1966, 2019
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Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults
,
Andrea A. Berry ,
Mark A. Travassos,
Kathy Strauss,
Matthew Adams,
Biraj Shrestha,
Tao Li,
Abraham Eappen,
Anita Manoj,
Yonas Abebe,
Tooba Murshedkar,
Anusha Gunasekera,
Thomas L. Richie,
Kirsten E. Lyke,
Christopher V. Plowe
and other authors.
Full text: Unavailable
Abstract
Abstract Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results in 100% infection rates. We conducted a double-blind, randomized, dose-escalation study to assess the infectivity of the 7G8 clone of Pf (PfSPZ Challenge [7G8]). Results showed dose-dependent infectivity from 43% for 8 × 102 PfSPZ to 100% for 4.8 × 103 PfSPZ. PfSPZ Challenge (7G8) will allow for more complete assessment by CHMI of antimalarial vaccines and drugs.