Dissemin is shutting down on January 1st, 2025

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Hindawi, Case Reports in Rheumatology, (2019), p. 1-9, 2019

DOI: 10.1155/2019/1326734

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A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature

Journal article published in 2019 by Bicky Thapa ORCID, Asad Ali, Raunak Nair, Rishik Vashisht, Cassandra Calabrese ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingly recognized. We report a challenging case of severe immune-related seronegative inflammatory arthritis due to nivolumab in a patient with stage IV metastatic adenocarcinoma.