Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3-Azabicyclo[4.1.0]hept-4-enes
Journal article published in 2015 by
Frederick Nuter,
Abdou Khadre Djily Dime,
Cheng Chen,
Lotfi Bounaadja,
Elisabeth Mouray,
Isabelle Florent,
Yvan Six,
Olivier Buriez,
Angela Marinetti,
Arnaud Voituriez
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Abstract
A series of substituted 3-azabicyclo[4.1.0]hept-4-ene derivatives were prepared and analysed by cyclic voltammetry. Preparative aerobic electrochemical oxidation reactions were then carried out. Three original endoperoxides were isolated, characterised and subjected to antimalarial and cytotoxicity activity assays.