Associations of autozygosity with a broad range of human phenotypes

Clark, David W.; Okada, Yukinori; Moore, Kristjan H. S.; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L. K.; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M.; Baumbach, Clemens; Biino, Ginevra; Bixley, Matthew J.; Brumat, Marco; Chai, Jin-Fang; Corre, Tanguy; Cousminer, Diana L.; Dekker, Annelot M.; Eccles, David A.; van Eijk, Kristel R.; Fuchsberger, Christian; Gao, He; Germain, Marine; Gordon, Scott D.; de Haan, Hugoline G.; Harris, Sarah E.; Hofer, Edith; Huerta-Chagoya, Alicia; Igartua, Catherine; Jansen, Iris E.; Jia, Yucheng; Kacprowski, Tim; Karlsson, Torgny; Kleber, Marcus E.; Li, Shengchao Alfred; Li-Gao, Ruifang; Mahajan, Anubha; Matsuda, Koichi; Meidtner, Karina; Meng, Weihua; Montasser, May E.; van der Most, Peter J.; Munz, Matthias; Nutile, Teresa; Palviainen, Teemu; Prasad, Gauri; Prasad, Rashmi B.; Priyanka, Tallapragada Divya Sri; Rizzi, Federica; Salvi, Erika; Sapkota, Bishwa R.; Shriner, Daniel; Skotte, Line; Smart, Melissa C.; Smith, Albert Vernon; van der Spek, Ashley; Spracklen, Cassandra N.; Strawbridge, Rona J.; Tajuddin, Salman M.; Trompet, Stella; Turman, Constance; Verweij, Niek; Viberti, Clara; Wang, Lihua; Warren, Helen R.; Wootton, Robyn E.; Yanek, Lisa R.; Yao, Jie; Yousri, Noha A.; Zhao, Wei; Adeyemo, Adebowale A.; Afaq, Saima; Aguilar-Salinas, Carlos Alberto; Akiyama, Masato; Albert, Matthew L.; Allison, Matthew A.; Alver, Maris; Aung, Tin; Azizi, Fereidoun; Bentley, Amy R.; Boeing, Heiner; Boerwinkle, Eric; Borja, Judith B.; de Borst, Gert J.; Bottinger, Erwin P.; Broer, Linda; Campbell, Harry; Chanock, Stephen; Chee, Miao-Li; Chen, Guanjie; Chen, Yii-Der I.; Chen, Zhengming; Chiu, Yen-Feng; Cocca, Massimiliano; Collins, Francis S.; Concas, Maria Pina; Corley, Janie; Cugliari, Giovanni; van Dam, Rob M.; Damulina, Anna; Daneshpour, Maryam S.; Day, Felix R.; Delgado, Graciela E.; Dhana, Klodian; Doney, Alexander S. F.; Dörr, Marcus; Doumatey, Ayo P.; Dzimiri, Nduna; Ebenesersdóttir, S. Sunna; Elliott, Joshua; Elliott, Paul; Ewert, Ralf; Felix, Janine F.; Fischer, Krista; Freedman, Barry I.; Girotto, Giorgia; Goel, Anuj; Gögele, Martin; Goodarzi, Mark O.; Graff, Mariaelisa; Granot-Hershkovitz, Einat; Grodstein, Francine; Guarrera, Simonetta; Gudbjartsson, Daniel F.; Guity, Kamran; Gunnarsson, Bjarni; Guo, Yu; Hagenaars, Saskia P.; Haiman, Christopher A.; Halevy, Avner; Harris, Tamara B.; Hedayati, Mehdi; van Heel, David A.; Hirata, Makoto; Höfer, Imo; Hsiung, Chao Agnes; Huang, Jinyan; Hung, Yi-Jen; Ikram, M. Arfan; Jagadeesan, Anuradha; Jousilahti, Pekka; Kamatani, Yoichiro; Kanai, Masahiro; Kerrison, Nicola D.; Kessler, Thorsten; Khaw, Kay-Tee; Khor, Chiea Chuen; de Kleijn, Dominique P. V.; Koh, Woon-Puay; Kolcic, Ivana; Kraft, Peter; Krämer, Bernhard K.; Kutalik, Zoltán; Kuusisto, Johanna; Langenberg, Claudia; Launer, Lenore J.; Lawlor, Deborah A.; Lee, I.-Te; Lee, Wen-Jane; Lerch, Markus M.; Li, Liming; Liu, Jianjun; Loh, Marie; London, Stephanie J.; Loomis, Stephanie; Lu, Yingchang; Luan, Jian’an; Mägi, Reedik; Manichaikul, Ani W.; Manunta, Paolo; Másson, Gísli; Matoba, Nana; Mei, Xue W.; Meisinger, Christa; Meitinger, Thomas; Mezzavilla, Massimo; Milani, Lili; Millwood, Iona Y.; Momozawa, Yukihide; Moore, Amy; Morange, Pierre-Emmanuel; Moreno-Macías, Hortensia; Mori, Trevor A.; Morrison, Alanna C.; Muka, Taulant; Murakami, Yoshinori; Murray, Alison D.; de Mutsert, Renée; Mychaleckyj, Josyf C.; Nalls, Mike A.; Nauck, Matthias; Neville, Matt J.; Nolte, Ilja M.; Ong, Ken K.; Orozco, Lorena; Padmanabhan, Sandosh; Pálsson, Gunnar; Pankow, James S.; Pattaro, Cristian; Pattie, Alison; Polasek, Ozren; Poulter, Neil; Pramstaller, Peter P.; Quintana-Murci, Lluis; Räikkönen, Katri; Ralhan, Sarju; Rao, Dabeeru C.; van Rheenen, Wouter; Rich, Stephen S.; Ridker, Paul M.; Rietveld, Cornelius A.; Robino, Antonietta; van Rooij, Frank J. A.; Ruggiero, Daniela; Saba, Yasaman; Sabanayagam, Charumathi; Sabater-Lleal, Maria; Sala, Cinzia Felicita; Salomaa, Veikko; Sandow, Kevin; Schmidt, Helena; Scott, Laura J.; Scott, William R.; Sedaghati-Khayat, Bahareh; Sennblad, Bengt; van Setten, Jessica; Sever, Peter J.; Sheu, Wayne H.-H.; Shi, Yuan; Shrestha, Smeeta; Shukla, Sharvari Rahul; Sigurdsson, Jon K.; Sikka, Timo Tonis; Singh, Jai Rup; Smith, Blair H.; Stančáková, Alena; Stanton, Alice; Starr, John M.; Stefansdottir, Lilja; Straker, Leon; Sulem, Patrick; Sveinbjornsson, Gardar; Swertz, Morris A.; Taylor, Adele M.; Taylor, Kent D.; Terzikhan, Natalie; Tham, Yih-Chung; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tillander, Annika; Tracy, Russell P.; Tusié-Luna, Teresa; Tzoulaki, Ioanna; Vaccargiu, Simona; Vangipurapu, Jagadish; Veldink, Jan H.; Vitart, Veronique; Völker, Uwe; Vuoksimaa, Eero; Wakil, Salma M.; Waldenberger, Melanie; Wander, Gurpreet S.; Wang, Ya Xing; Wareham, Nicholas J.; Wild, Sarah; Yajnik, Chittaranjan S.; Yuan, Jian-Min; Zeng, Lingyao; Zhang, Liang; Zhou, Jie; Amin, Najaf; Asselbergs, Folkert W.; Bakker, Stephan J. L.; Becker, Diane M.; Lehne, Benjamin; Bennett, David A.; van den Berg, Leonard H.; Berndt, Sonja I.; Bharadwaj, Dwaipayan; Bielak, Lawrence F.; Bochud, Murielle; Boehnke, Mike; Bouchard, Claude; Bradfield, Jonathan P.; Brody, Jennifer A.; Campbell, Archie; Carmi, Shai; Caulfield, Mark J.; Cesarini, David; Chambers, John C.; Chandak, Giriraj Ratan; Cheng, Ching-Yu; Ciullo, Marina; Cornelis, Marilyn; Cusi, Daniele; Smith, George Davey; Deary, Ian J.; Dorajoo, Rajkumar; van Duijn, Cornelia M.; Ellinghaus, David; Erdmann, Jeanette; Eriksson, Johan G.; Evangelou, Evangelos; Evans, Michele K.; Faul, Jessica D.; Feenstra, Bjarke; Feitosa, Mary; Foisy, Sylvain; Franke, Andre; Friedlander, Yechiel; Gasparini, Paolo; Gieger, Christian; Gonzalez, Clicerio; Goyette, Philippe; Grant, Struan F. A.; Griffiths, Lyn R.; Groop, Leif; Gudnason, Vilmundur; Gyllensten, Ulf; Hakonarson, Hakon; Hamsten, Anders; van der Harst, Pim; Heng, Chew-Kiat; Hicks, Andrew A.; Hochner, Hagit; Huikuri, Heikki; Hunt, Steven C.; Jaddoe, Vincent W. V.; De Jager, Philip L.; Johannesson, Magnus; Johansson, Åsa; Jonas, Jost B.; Jukema, J. Wouter; Junttila, Juhani; Kaprio, Jaakko; Kardia, Sharon L. R.; Karpe, Fredrik; Kumari, Meena; Laakso, Markku; van der Laan, Sander W.; Lahti, Jari; Laudes, Matthias; Lea, Rodney A.; Lieb, Wolfgang; Lumley, Thomas; Martin, Nicholas G.; März, Winfried; Matullo, Giuseppe; McCarthy, Mark I.; Medland, Sarah E.; Merriman, Tony R.; Metspalu, Andres; Meyer, Brian F.; Mohlke, Karen L.; Montgomery, Grant W.; Mook-Kanamori, Dennis; Munroe, Patricia B.; North, Kari E.; Nyholt, Dale R.; O’connell, Jeffery R.; Ober, Carole; Oldehinkel, Albertine J.; Palmas, Walter; Palmer, Colin; Pasterkamp, Gerard G.; Patin, Etienne; Pennell, Craig E.; Perusse, Louis; Peyser, Patricia A.; Pirastu, Mario; Polderman, Tinca J. C.; Porteous, David J.; Posthuma, Danielle; Psaty, Bruce M.; Rioux, John D.; Rivadeneira, Fernando; Rotimi, Charles; Rotter, Jerome I.; Rudan, Igor; Den Ruijter, Hester M.; Sanghera, Dharambir K.; Sattar, Naveed; Schmidt, Reinhold; Schulze, Matthias B.; Schunkert, Heribert; Scott, Robert A.; Shuldiner, Alan R.; Sim, Xueling; Small, Neil; Smith, Jennifer A.; Sotoodehnia, Nona; Tai, E.-Shyong; Teumer, Alexander; Timpson, Nicholas J.; Toniolo, Daniela; Tregouet, David-Alexandre; Tuomi, Tiinamaija; Vollenweider, Peter; Wang, Carol A.; Weir, David R.; Whitfield, John B.; Wijmenga, Cisca; Wong, Tien-Yin; Wright, John; Yang, Jingyun; Yu, Lei; Zemel, Babette S.; Zonderman, Alan B.; Perola, Markus; Magnusson, Patrik K. E.; Uitterlinden, André G.; Kooner, Jaspal S.; Chasman, Daniel I.; Loos, Ruth J. F.; Franceschini, Nora; Franke, Lude; Haley, Chris S.; Hayward, Caroline; Walters, Robin G.; Perry, John R. B.; Esko, Tōnu; Helgason, Agnar; Stefansson, Kari; Joshi, Peter K.; Kubo, Michiaki; Wilson, James F.

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David Clark
Clark et al., 2019

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Nature Research, Nature Communications, 1(10), 2019

DOI: 10.1038/s41467-019-12283-6

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@article{Clark2019,
  author = {Clark, David W. and Okada, Yukinori and Moore, Kristjan H. S. and Mason, Dan and Pirastu, Nicola and Gandin, Ilaria and Mattsson, Hannele and Barnes, Catriona L. K. and Lin, Kuang and Zhao, Jing Hua and Deelen, Patrick and Rohde, Rebecca and Schurmann, Claudia and Guo, Xiuqing and Giulianini, Franco and Zhang, Weihua and Medina-Gomez, Carolina and Karlsson, Robert and Bao, Yanchun and Bartz, Traci M. and Baumbach, Clemens and Biino, Ginevra and Bixley, Matthew J. and Brumat, Marco and Chai, Jin-Fang and Corre, Tanguy and Cousminer, Diana L. and Dekker, Annelot M. and Eccles, David A. and van Eijk, Kristel R. and Fuchsberger, Christian and Gao, He and Germain, Marine and Gordon, Scott D. and de Haan, Hugoline G. and Harris, Sarah E. and Hofer, Edith and Huerta-Chagoya, Alicia and Igartua, Catherine and Jansen, Iris E. and Jia, Yucheng and Kacprowski, Tim and Karlsson, Torgny and Kleber, Marcus E. and Li, Shengchao Alfred and Li-Gao, Ruifang and Mahajan, Anubha and Matsuda, Koichi and Meidtner, Karina and Meng, Weihua and Montasser, May E. and van der Most, Peter J. and Munz, Matthias and Nutile, Teresa and Palviainen, Teemu and Prasad, Gauri and Prasad, Rashmi B. and Priyanka, Tallapragada Divya Sri and Rizzi, Federica and Salvi, Erika and Sapkota, Bishwa R. and Shriner, Daniel and Skotte, Line and Smart, Melissa C. and Smith, Albert Vernon and van der Spek, Ashley and Spracklen, Cassandra N. and Strawbridge, Rona J. and Tajuddin, Salman M. and Trompet, Stella and Turman, Constance and Verweij, Niek and Viberti, Clara and Wang, Lihua and Warren, Helen R. and Wootton, Robyn E. and Yanek, Lisa R. and Yao, Jie and Yousri, Noha A. and Zhao, Wei and Adeyemo, Adebowale A. and Afaq, Saima and Aguilar-Salinas, Carlos Alberto and Akiyama, Masato and Albert, Matthew L. and Allison, Matthew A. and Alver, Maris and Aung, Tin and Azizi, Fereidoun and Bentley, Amy R. and Boeing, Heiner and Boerwinkle, Eric and Borja, Judith B. and de Borst, Gert J. and Bottinger, Erwin P. and Broer, Linda and Campbell, Harry and Chanock, Stephen and Chee, Miao-Li and Chen, Guanjie and Chen, Yii-Der I. and Chen, Zhengming and Chiu, Yen-Feng and Cocca, Massimiliano and Collins, Francis S. and Concas, Maria Pina and Corley, Janie and Cugliari, Giovanni and van Dam, Rob M. and Damulina, Anna and Daneshpour, Maryam S. and Day, Felix R. and Delgado, Graciela E. and Dhana, Klodian and Doney, Alexander S. F. and Dörr, Marcus and Doumatey, Ayo P. and Dzimiri, Nduna and Ebenesersdóttir, S. Sunna and Elliott, Joshua and Elliott, Paul and Ewert, Ralf and Felix, Janine F. and Fischer, Krista and Freedman, Barry I. and Girotto, Giorgia and Goel, Anuj and Gögele, Martin and Goodarzi, Mark O. and Graff, Mariaelisa and Granot-Hershkovitz, Einat and Grodstein, Francine and Guarrera, Simonetta and Gudbjartsson, Daniel F. and Guity, Kamran and Gunnarsson, Bjarni and Guo, Yu and Hagenaars, Saskia P. and Haiman, Christopher A. and Halevy, Avner and Harris, Tamara B. and Hedayati, Mehdi and van Heel, David A. and Hirata, Makoto and Höfer, Imo and Hsiung, Chao Agnes and Huang, Jinyan and Hung, Yi-Jen and Ikram, M. Arfan and Jagadeesan, Anuradha and Jousilahti, Pekka and Kamatani, Yoichiro and Kanai, Masahiro and Kerrison, Nicola D. and Kessler, Thorsten and Khaw, Kay-Tee and Khor, Chiea Chuen and de Kleijn, Dominique P. V. and Koh, Woon-Puay and Kolcic, Ivana and Kraft, Peter and Krämer, Bernhard K. and Kutalik, Zoltán and Kuusisto, Johanna and Langenberg, Claudia and Launer, Lenore J. and Lawlor, Deborah A. and Lee, I.-Te and Lee, Wen-Jane and Lerch, Markus M. and Li, Liming and Liu, Jianjun and Loh, Marie and London, Stephanie J. and Loomis, Stephanie and Lu, Yingchang and Luan, Jian’an and Mägi, Reedik and Manichaikul, Ani W. and Manunta, Paolo and Másson, Gísli and Matoba, Nana and Mei, Xue W. and Meisinger, Christa and Meitinger, Thomas and Mezzavilla, Massimo and Milani, Lili and Millwood, Iona Y. and Momozawa, Yukihide and Moore, Amy and Morange, Pierre-Emmanuel and Moreno-Macías, Hortensia and Mori, Trevor A. and Morrison, Alanna C. and Muka, Taulant and Murakami, Yoshinori and Murray, Alison D. and de Mutsert, Renée and Mychaleckyj, Josyf C. and Nalls, Mike A. and Nauck, Matthias and Neville, Matt J. and Nolte, Ilja M. and Ong, Ken K. and Orozco, Lorena and Padmanabhan, Sandosh and Pálsson, Gunnar and Pankow, James S. and Pattaro, Cristian and Pattie, Alison and Polasek, Ozren and Poulter, Neil and Pramstaller, Peter P. and Quintana-Murci, Lluis and Räikkönen, Katri and Ralhan, Sarju and Rao, Dabeeru C. and van Rheenen, Wouter and Rich, Stephen S. and Ridker, Paul M. and Rietveld, Cornelius A. and Robino, Antonietta and van Rooij, Frank J. A. and Ruggiero, Daniela and Saba, Yasaman and Sabanayagam, Charumathi and Sabater-Lleal, Maria and Sala, Cinzia Felicita and Salomaa, Veikko and Sandow, Kevin and Schmidt, Helena and Scott, Laura J. and Scott, William R. and Sedaghati-Khayat, Bahareh and Sennblad, Bengt and van Setten, Jessica and Sever, Peter J. and Sheu, Wayne H.-H. and Shi, Yuan and Shrestha, Smeeta and Shukla, Sharvari Rahul and Sigurdsson, Jon K. and Sikka, Timo Tonis and Singh, Jai Rup and Smith, Blair H. and Stančáková, Alena and Stanton, Alice and Starr, John M. and Stefansdottir, Lilja and Straker, Leon and Sulem, Patrick and Sveinbjornsson, Gardar and Swertz, Morris A. and Taylor, Adele M. and Taylor, Kent D. and Terzikhan, Natalie and Tham, Yih-Chung and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Tillander, Annika and Tracy, Russell P. and Tusié-Luna, Teresa and Tzoulaki, Ioanna and Vaccargiu, Simona and Vangipurapu, Jagadish and Veldink, Jan H. and Vitart, Veronique and Völker, Uwe and Vuoksimaa, Eero and Wakil, Salma M. and Waldenberger, Melanie and Wander, Gurpreet S. and Wang, Ya Xing and Wareham, Nicholas J. and Wild, Sarah and Yajnik, Chittaranjan S. and Yuan, Jian-Min and Zeng, Lingyao and Zhang, Liang and Zhou, Jie and Amin, Najaf and Asselbergs, Folkert W. and Bakker, Stephan J. L. and Becker, Diane M. and Lehne, Benjamin and Bennett, David A. and van den Berg, Leonard H. and Berndt, Sonja I. and Bharadwaj, Dwaipayan and Bielak, Lawrence F. and Bochud, Murielle and Boehnke, Mike and Bouchard, Claude and Bradfield, Jonathan P. and Brody, Jennifer A. and Campbell, Archie and Carmi, Shai and Caulfield, Mark J. and Cesarini, David and Chambers, John C. and Chandak, Giriraj Ratan and Cheng, Ching-Yu and Ciullo, Marina and Cornelis, Marilyn and Cusi, Daniele and Smith, George Davey and Deary, Ian J. and Dorajoo, Rajkumar and van Duijn, Cornelia M. and Ellinghaus, David and Erdmann, Jeanette and Eriksson, Johan G. and Evangelou, Evangelos and Evans, Michele K. and Faul, Jessica D. and Feenstra, Bjarke and Feitosa, Mary and Foisy, Sylvain and Franke, Andre and Friedlander, Yechiel and Gasparini, Paolo and Gieger, Christian and Gonzalez, Clicerio and Goyette, Philippe and Grant, Struan F. A. and Griffiths, Lyn R. and Groop, Leif and Gudnason, Vilmundur and Gyllensten, Ulf and Hakonarson, Hakon and Hamsten, Anders and van der Harst, Pim and Heng, Chew-Kiat and Hicks, Andrew A. and Hochner, Hagit and Huikuri, Heikki and Hunt, Steven C. and Jaddoe, Vincent W. V. and De Jager, Philip L. and Johannesson, Magnus and Johansson, Åsa and Jonas, Jost B. and Jukema, J. Wouter and Junttila, Juhani and Kaprio, Jaakko and Kardia, Sharon L. R. and Karpe, Fredrik and Kumari, Meena and Laakso, Markku and van der Laan, Sander W. and Lahti, Jari and Laudes, Matthias and Lea, Rodney A. and Lieb, Wolfgang and Lumley, Thomas and Martin, Nicholas G. and März, Winfried and Matullo, Giuseppe and McCarthy, Mark I. and Medland, Sarah E. and Merriman, Tony R. and Metspalu, Andres and Meyer, Brian F. and Mohlke, Karen L. and Montgomery, Grant W. and Mook-Kanamori, Dennis and Munroe, Patricia B. and North, Kari E. and Nyholt, Dale R. and O’connell, Jeffery R. and Ober, Carole and Oldehinkel, Albertine J. and Palmas, Walter and Palmer, Colin and Pasterkamp, Gerard G. and Patin, Etienne and Pennell, Craig E. and Perusse, Louis and Peyser, Patricia A. and Pirastu, Mario and Polderman, Tinca J. C. and Porteous, David J. and Posthuma, Danielle and Psaty, Bruce M. and Rioux, John D. and Rivadeneira, Fernando and Rotimi, Charles and Rotter, Jerome I. and Rudan, Igor and Den Ruijter, Hester M. and Sanghera, Dharambir K. and Sattar, Naveed and Schmidt, Reinhold and Schulze, Matthias B. and Schunkert, Heribert and Scott, Robert A. and Shuldiner, Alan R. and Sim, Xueling and Small, Neil and Smith, Jennifer A. and Sotoodehnia, Nona and Tai, E.-Shyong and Teumer, Alexander and Timpson, Nicholas J. and Toniolo, Daniela and Tregouet, David-Alexandre and Tuomi, Tiinamaija and Vollenweider, Peter and Wang, Carol A. and Weir, David R. and Whitfield, John B. and Wijmenga, Cisca and Wong, Tien-Yin and Wright, John and Yang, Jingyun and Yu, Lei and Zemel, Babette S. and Zonderman, Alan B. and Perola, Markus and Magnusson, Patrik K. E. and Uitterlinden, André G. and Kooner, Jaspal S. and Chasman, Daniel I. and Loos, Ruth J. F. and Franceschini, Nora and Franke, Lude and Haley, Chris S. and Hayward, Caroline and Walters, Robin G. and Perry, John R. B. and Esko, Tōnu and Helgason, Agnar and Stefansson, Kari and Joshi, Peter K. and Kubo, Michiaki and Wilson, James F.},
  doi = {10.1038/s41467-019-12283-6},
  journal = {Nature Communications},
  month = {oct},
  title = {Associations of autozygosity with a broad range of human phenotypes},
  url = {https://doi.org/10.1038/s41467-019-12283-6},
  volume = {10},
  year = {2019}
}

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