Published in
Oxford University Press, Brain, 11(142), p. 3325-3337, 2019
DOI: 10.1093/brain/awz222
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Targeting the complement system in bacterial meningitis
Journal article published in 2019 by
Diederik L. H. Koelman,
Matthijs C. Brouwer,
Diederik van de Beek 
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Abstract
Morbidity and mortality in bacterial meningitis are driven by an uncontrolled host inflammatory response. Koelman et al. evaluate the detrimental role of the complement system in spurring this inflammation, and conclude that anaphylatoxin C5a is a promising treatment target in bacterial meningitis.