Published in
Oxford University Press, Brain, 11(142), p. 3411-3427, 2019
DOI: 10.1093/brain/awz301
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Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis
Journal article published in 2019 by
Sebastian Herich 
,
Tilman Schneider-Hohendorf ,
Astrid Rohlmann,
Maryam Khaleghi Ghadiri,
Andreas Schulte-Mecklenbeck,
Lisa Zondler,
Claudia Janoschka,
Patrick Ostkamp ,
Jannis Richter,
Johanna Breuer,
Stoyan Dimitrov ,
Hans-Georg Rammensee,
Oliver M. Grauer,
Luisa Klotz,
Catharina C. Gross
and other authors.
,
Tilman Schneider-Hohendorf ,
Astrid Rohlmann,
Maryam Khaleghi Ghadiri,
Andreas Schulte-Mecklenbeck,
Lisa Zondler,
Claudia Janoschka,
Patrick Ostkamp ,
Jannis Richter,
Johanna Breuer,
Stoyan Dimitrov ,
Hans-Georg Rammensee,
Oliver M. Grauer,
Luisa Klotz,
Catharina C. Gross
and other authors.
This paper is made freely available by the publisher.
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Abstract
Specific immune-cell populations patrol the CNS in search of pathogens and tumours. Herich et al. identify CD4+ CCR5high GzmK+ effector-memory cells as a brain-surveilling subpopulation capable of crossing the uninflamed blood-brain barrier, and reveal alterations in this population in HIV+ patients with neurological symptoms and in patients with multiple sclerosis.