Published in
Royal Society of Chemistry, Chemical Science, 3(10), p. 815-828, 2019
DOI: 10.1039/c8sc03409e
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A synthetic approach to ‘click’ neoglycoprotein analogues of EPO employing one-pot native chemical ligation and CuAAC chemistry
Journal article published in 2019 by
D. J. Lee,
A. J. Cameron 
,
T. H. Wright ,
P. W. R. Harris ,
M. A. Brimble
,
T. H. Wright ,
P. W. R. Harris ,
M. A. Brimble
This paper is made freely available by the publisher.
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Abstract
The batch-wise variability of commercial erythropoietin (EPO) preparations warrants development of more advanced synthetic methodologies. We have developed a diverse chemical toolkit to prepare ‘click’ neoglycoprotein variants of EPO.