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SAGE Publications, International Journal of Stroke, 8(14), p. 792-802, 2019

DOI: 10.1177/1747493019879657

SAGE Publications, Neurorehabilitation and Neural Repair, 11(33), p. 959-969, 2019

DOI: 10.1177/1545968319888642

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A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Journal article published in 2019 by Julie Bernhardt, Nick S. Ward, Kathryn S. Hayward ORCID, Hayward Ks, Numa Dancause, Natasha A. Lannin ORCID, Lannin Na, Ward Ns, Randolph J. Nudo, Nudo Rj, Amanda Farrin ORCID, Leonid Churilov, Lara A. Boyd ORCID, Boyd La, Theresa A. Jones and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.