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MDPI, Molecules, 21(24), p. 3846, 2019

DOI: 10.3390/molecules24213846

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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates

Journal article published in 2019 by Mara Tomassetti, Gabriele Lupidi, Pamela Piermattei, Federico V. Rossi, Samuele Lillini, Gianluca Bianchini, Andrea Aramini ORCID, Marco A. Ciufolini, Enrico Marcantoni ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.