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Published in

American Society for Microbiology, Journal of Clinical Microbiology, 11(57), 2019

DOI: 10.1128/jcm.00782-19

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Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine

Journal article published in 2019 by Kanagavel Murugesan ORCID, Catherine A. Hogan, Zaida Palmer, Byron Reeve, Grant Theron, Alfred Andama, Akos Somoskovi, Amy Steadman, Damian Madan, Jason Andrews, Julio Croda ORCID, Malaya K. Sahoo, Adithya Cattamanchi, Benjamin A. Pinsky ORCID, Niaz Banaei
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Pathogen cell-free DNA (pcfDNA) in blood and urine is an attractive biomarker; however, the impact of preanalytical factors is not well understood. Blood and urine samples from healthy donors spiked with cfDNA from Mycobacterium tuberculosis , Salmonella enterica , Aspergillus fumigatus , and Epstein-Barr virus (EBV) and samples from tuberculosis patients were used to evaluate the impact of blood collection tube, urine preservative, processing delay, processing method, freezing and thawing, and sample volume on pcfDNA.