Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(63), 2019
DOI: 10.1128/aac.00448-19
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20S Proteasome as a Drug Target in Trichomonas vaginalis
Journal article published in 2019 by
Anthony J. O’Donoghue 
,
Betsaida Bibo-Verdugo,
Yukiko Miyamoto,
Steven C. Wang,
Justin Z. Yang,
Douglas E. Zuill,
Shoun Matsuka,
Zhenze Jiang ,
Jehad Almaliti,
Conor R. Caffrey,
William H. Gerwick,
Lars Eckmann
,
Betsaida Bibo-Verdugo,
Yukiko Miyamoto,
Steven C. Wang,
Justin Z. Yang,
Douglas E. Zuill,
Shoun Matsuka,
Zhenze Jiang ,
Jehad Almaliti,
Conor R. Caffrey,
William H. Gerwick,
Lars Eckmann
This paper is made freely available by the publisher.
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Abstract
Trichomoniasis is a sexually transmitted disease with hundreds of millions of annual cases worldwide. Approved treatment options are limited to two related nitro-heterocyclic compounds, yet resistance to these drugs is an increasing concern. New antimicrobials against the causative agent, Trichomonas vaginalis , are urgently needed.