Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).

Parkesh, Raman; Vasudevan, Sridhar R.; Berry, Alexandra; Galione, Antony; Dowden, James; Churchill, Gc

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Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).

Journal article published in 2007 by Raman Parkesh, Sridhar R. Vasudevan, Alexandra Berry, Antony Galione, James Dowden

, Gc Churchill

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Abstract

A chemo-enzymatic synthesis of novel caged NAADP+ without the formation of multiple cage compounds has been achieved. The biological activity of the caged NAADP+ was demonstrated by its fast uncaging in intact sea-urchin eggs.