AbstractContrast-enhanced ultrasound (CEUS) has been widely accepted as a diagnostic tool for the detection and evaluation of benign and malignant liver lesions and has been implemented into the clinical routine as a tool for percutaneous interventional real-time image guidance. CEUS can be combined with computed tomography (CT) and magnetic resonance imaging (MRI) datasets using real-time image fusion to additionally surveil proper interventional treatment and assess treatment success. This review describes the state-of-the-art use of CEUS for the surveillance and monitoring of interventional procedures of the liver and for the evaluation of postinterventional success.