Emerging evidence suggests that cognitive-behavioral interventions should be considered as a first-line treatment for adolescent sleep problems and can also address associated mental health concerns. This article’s aim is to prioritize future directions for this research. Studies are needed that (a) leverage innovative technology, which may allow for a more personalized-medicine approach to care; (b) use alternative research designs, such as treatment-optimization strategies; (c) evaluate mechanisms of therapeutic improvements, including mediators and moderators of change, predictors of treatment adherence, dose–response relationships, and specificity of effects of different treatment components; (d) “scale up” the interventions so that a large proportion of adolescents can access them; and (e) develop flexible approaches to delivery (e.g., online platforms) and stepped-care guidelines. National and international standards of secondary school start times of 8:30 a.m. or later are also needed. The field is now mature enough to take these next steps, which will enhance the effectiveness and public health impact of these interventions.