Dissemin is shutting down on January 1st, 2025

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Springer Nature [academic journals on nature.com], Leukemia, 1(25), p. 178-181, 2010

DOI: 10.1038/leu.2010.236

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IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis

Journal article published in 2010 by S. Soverini, J. Score, I. Iacobucci, A. Poerio, A. Lonetti, A. Gnani, S. Colarossi, A. Ferrari ORCID, F. Castagnetti, G. Rosti, F. Cervantes, A. Hochhaus, Massimo Delledonne, Alberto Ferrarini, M. Sazzini and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We read with interest a series of manuscripts,1, 2, 3, 4, 5, 6 reporting somatic mutations of the isocitrate dehydrogenase 1 and 2 enzyme isoforms (IDH1, IDH2) in patients with de novo acute myeloid leukemia (AML), in patients with chronic and blast phase Philadelphia chromosome-negative (Ph–) myeloproliferative neoplasms (MPNs) and in patients with early and accelerated phase myelodysplastic syndromes (MDSs).We have recently screened, by massively parallel sequencing, the transcriptome of a Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) patient