A Versatile Setup for Time-Resolved Functional Near Infrared Spectroscopy Based on Fast-Gated Single-Photon Avalanche Diode and on Four-Wave Mixing Laser
Journal article published in 2019 by
Laura Di Sieno,
Alberto Dalla Mora 
,
Alessandro Torricelli,
Lorenzo Spinelli,
Rebecca Re ,
Antonio Pifferi ,
Davide Contini
,
Alessandro Torricelli,
Lorenzo Spinelli,
Rebecca Re ,
Antonio Pifferi ,
Davide Contini
This paper is made freely available by the publisher.
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Abstract
In this paper, a time-domain fast gated near-infrared spectroscopy system is presented. The system is composed of a fiber-based laser providing two pulsed sources and two fast gated detectors. The system is characterized on phantoms and was tested in vivo, showing how the gating approach can improve the contrast and contrast-to-noise-ratio for detection of absorption perturbation inside a diffusive medium, regardless of source-detector separation.