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Medknow Publications, International Journal of Mycobacteriology, 5(9), p. 6, 2021

DOI: 10.4103/2212-5531.307111

American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(63), 2019

DOI: 10.1128/aac.00915-19

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Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan

Journal article published in 2019 by Arash Ghodousi ORCID, Alamdar Hussain Rizvi, Aurangzaib Quadir Baloch, Abdul Ghafoor, Faisal Masood Khanzada, Mehmood Qadir, Emanuele Borroni ORCID, Alberto Trovato ORCID, Sabira Tahseen ORCID, Daniela Maria Cirillo ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment.