Published in
American Society for Microbiology, Infection and Immunity, 7(87), 2019
DOI: 10.1128/iai.00865-18
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Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region
Journal article published in 2019 by
Justin Doritchamou 
,
Andrew Teo,
Robert Morrison,
Gunjan Arora,
Jennifer Kwan,
Javier Manzella-Lapeira,
Sarimar Medina-Maldonado,
Jean Langhorne,
Lars Hviid ,
David L. Narum,
Alassane Dicko,
Michal Fried,
Patrick E. Duffy
,
Andrew Teo,
Robert Morrison,
Gunjan Arora,
Jennifer Kwan,
Javier Manzella-Lapeira,
Sarimar Medina-Maldonado,
Jean Langhorne,
Lars Hviid ,
David L. Narum,
Alassane Dicko,
Michal Fried,
Patrick E. Duffy
This paper is made freely available by the publisher.
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Abstract
During pregnancy, Plasmodium falciparum -infected erythrocytes (IE) accumulate in the intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit inflammatory responses that are associated with poor pregnancy outcomes. Primigravidae lack immunity to IE that sequester in the placenta and thus are susceptible to placental malaria (PM).