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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(63), 2019

DOI: 10.1128/aac.00548-19

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Elevated Prevalence of Azole-Resistant Aspergillus fumigatus in Urban versus Rural Environments in the United Kingdom

Journal article published in 2019 by Thomas R. Sewell ORCID, Yuyi Zhang, Amelie P. Brackin, Jennifer M. G. Shelton ORCID, Johanna Rhodes ORCID, Matthew C. Fisher ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Azole resistance in the opportunistic pathogen Aspergillus fumigatus is increasing, dominated primarily by the following two environmentally associated resistance alleles: TR 34 /L98H and TR 46 /Y121F/T289A. By sampling soils across the South of England, we assess the prevalence of azole-resistant A. fumigatus (AR Af ) in samples collected in both urban and rural locations.