Published in

Elsevier, European Journal of Medicinal Chemistry, 4(46), p. 1439-1447, 2011

DOI: 10.1016/j.ejmech.2011.01.027

Links

Tools

Export citation

Search in Google Scholar

Synthesis and biological evaluation of indazole derivatives

Journal article published in 2011 by Rm Claramunt, Concepción Lopez, Ana Lopez, Carlos Perez-Medina, Marta Perez-Torralba, Ibon Alkorta ORCID, José Elguero, Germaine Escames, Darío Acuna-Castroviejo ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibition percentage with the difference, E-rel, between stacking and apical interaction energies of indazoles with the active site of the NOS enzyme has been established. (c) 2011 Elsevier Masson SAS. All rights reserved.