Published in
IUPHAR/BPS Guide to Pharmacology CITE, 4(2019), 2019
DOI: 10.2218/gtopdb/f58/2019.4
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Prostanoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Journal article published in 2019 by
Richard M. Breyer,
Lucie Clapp 
,
Robert A. Coleman,
Mark Giembycz,
Akos Heinemann ,
Rebecca Hills,
Robert L. Jones,
Shuh Narumiya,
Xavier Norel ,
Roy Pettipher,
Yukihiko Sugimoto,
David F. Woodward,
Chengcan Yao
,
Robert A. Coleman,
Mark Giembycz,
Akos Heinemann ,
Rebecca Hills,
Robert L. Jones,
Shuh Narumiya,
Xavier Norel ,
Roy Pettipher,
Yukihiko Sugimoto,
David F. Woodward,
Chengcan Yao
Abstract
Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [644]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.