Published in
Oxford University Press (OUP), Clinical Infectious Diseases, 2019
DOI: 10.1093/cid/ciz692
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Factors Influencing the Incubation of an Infectious Form of Creutzfeldt-Jakob Disease
Journal article published in 2019 by
Laurène Peckeu 
,
Jean-Philippe Brandel,
Arlette Welaratne,
Elodie Amar,
Dominique Costagliola ,
Stéphane Haïk
,
Jean-Philippe Brandel,
Arlette Welaratne,
Elodie Amar,
Dominique Costagliola ,
Stéphane Haïk
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Abstract
Abstract The French epidemics of iatrogenic Creutzfeldt-Jakob disease after growth hormone (GH) treatment provide an opportunity to understand factors governing the inter-human transmission of prions. The present analysis relying on truncated Weibull distribution supports a relationship between host genetics, dose of the at-risk GH, age at treatment onset, and duration of the incubation period.