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Are Cox-2 drugs the second line option in indomethacin responsive headaches?
Journal article published in 2010 by
Jesús Porta-Etessam 
,
Marialuz Cuadrado,
Octavio Rodríguez-Gómez,
Sara García-Ptacek ,
Cristina Valencia
,
Marialuz Cuadrado,
Octavio Rodríguez-Gómez,
Sara García-Ptacek ,
Cristina Valencia
Abstract
Paroxysmal hemicrania and hemicrania continua are both indomethacin-responsive headaches. Although indomethacin use to be well tolerated, some patients developed gastrointestinal side effects. We report four cases of hemicrania continua and a patient suffering chronic paroxysmal hemicrania completely responsive to celecoxib. In our experience celecoxib is a good option treatment for patients suffering from hemicrania continua or chronic paroxysmal hemicranea that presents indomethacin adverse effects.