Published in
Public Library of Science, PLoS ONE, 10(6), p. e25888, 2011
DOI: 10.1371/journal.pone.0025888
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Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation
Journal article published in 2011 by
Gianna Palmieri,
Paolo Bergamo 
,
Alberto Luini,
Menotti Ruvo,
Marta Gogliettino,
Emma Langella,
Michele Saviano,
Ramanath N. Hegde,
Annamaria Sandomenico,
Mose Rossi
,
Alberto Luini,
Menotti Ruvo,
Marta Gogliettino,
Emma Langella,
Michele Saviano,
Ramanath N. Hegde,
Annamaria Sandomenico,
Mose Rossi
This paper is made freely available by the publisher.
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Abstract
Acylpeptide hydrolase (APEH), one of the four members of the prolyl oligopeptidase class, catalyses the removal of N-acylated amino acids from acetylated peptides and it has been postulated to play a key role in protein degradation machinery. Disruption of protein turnover has been established as an effective strategy to down-regulate the ubiquitin-proteasome system (UPS) and as a promising approach in anticancer therapy.