Background: Obesity is a health condition that causes a great impact on public health. The aim of this study was to determine the association between dermatoglyphic characteristics and excessive weight in children and adolescents aged 10 to 19 years in the center-west region of Santa Catarina, Brazil. Methods: The sample comprised of 2,172 children and adolescents aged 10 to 19 years old of both sexes and from public and private teaching networks. Results: The results suggested a predictive marker of obesity, with a greater number of lines in left hand finger two (Mesql2) and a higher frequency of the whorl pattern in participants of a healthy weight, while the overweight group had a higher frequency of the radial loop pattern and the obese group had a higher frequency of the ulnar loop pattern. Conclusion: It was concluded that there may be different dermatoglyphic characteristics depending on the nutritional status of children and adolescents.