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BioMed Central, BMC Genomics, 1(15), p. 730

DOI: 10.1186/1471-2164-15-730

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Gene co-expression network analysis in Rhodobacter capsulatus and application to comparative expression analysis of Rhodobacter sphaeroides

Journal article published in 2014 by Lourdes Peña-Castillo, Ryan G. Mercer, Anastasia Gurinovich, Stephen J. Callister, Aaron T. Wright, Alexander B. Westbye ORCID, J. Thomas Beatty, J. Thomas Beatty, Andrew S. Lang ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

CONCLUSIONS: Our analyses provide new sources of information for functional annotation in R. capsulatus because uncharacterized genes in modules are now connected with groups of genes that constitute a joint functional annotation. We identified R. capsulatus modules enriched with genes for ribosomal proteins, porphyrin and bacteriochlorophyll anabolism, and biosynthesis of secondary metabolites to be preserved in R. sphaeroides whereas modules related to RcGTA production and signalling showed lack of preservation in R. sphaeroides. In addition, we demonstrated that network statistics may also be applied within-species to identify congruence between mRNA expression and protein abundance data for which simple correlation measurements have previously had mixed results.