Published in

National Academy of Sciences, Proceedings of the National Academy of Sciences, 41(102), p. 14689-14693, 2005

DOI: 10.1073/pnas.0506465102

National Academy of Sciences, Proceedings of the National Academy of Sciences, 37(102), p. 13023-13028, 2005

DOI: 10.1073/pnas.0506455102

Links

Tools

Export citation

Search in Google Scholar

Marine phosphate oxygen isotopes and organic matter remineralization in the oceans

Journal article published in 2005 by A. S. Colman, R. E. Blake, D. M. Karl ORCID, M. L. Fogel, K. K. Turekian
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Red circle
Preprint: archiving forbidden
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Open Acess at http://www.pnas.org/cgi/content/abstract/0506465102v1 ; The initial analysis of the recently sequenced genome of Acanthamoeba polyphaga Mimivirus, the largest known double-stranded DNA virus, predicted a proteome of size and complexity more akin to small parasitic bacteria than to other nucleo-cytoplasmic large DNA viruses, and identified numerous functions never before described in a virus. It has been proposed that the Mimivirus lineage could have emerged before the individualization of cellular organisms from the 3 domains of life. An exhaustive in silico analysis of the non-coding moiety of all known viral genomes, now uncovers the unprecedented perfect conservation of a AAAATTGA motif in close to 50% of the Mimivirus genes. This motif preferentially occurs in genes transcribed from the predicted leading strand and is associated with functions required early in the viral infectious cycle, such as transcription and protein translation. A comparison with the known promoter of unicellular eukaryotes, in particular amoebal protists, strongly suggests that the AAAATTGA motif is the structural equivalent of the TATA box core promoter element. This element is specific to the Mimivirus lineage, and may correspond to an ancestral promoter structure predating the radiation of the eukaryotic kingdoms. This unprecedented conservation of core promoter regions is another exceptional features of Mimivirus, that again raises the question of its evolutionary origin.