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American Association for the Advancement of Science, Science, 6189(344), p. 1280-1285, 2014

DOI: 10.1126/science.1251688

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The Genetics of Mexico Recapitulates Native American Substructure and Affects Biomedical Traits

Journal article published in 2014 by Andrés Moreno-Estrada, Blanca del Rio Navarro, Christopher R. Gignoux, Juan Carlos Fernández-López ORCID, Fouad Zakharia, Martin Sikora, Alejandra V. Contreras ORCID, Victor Acuña-Alonzo, Karla Sandoval ORCID, Celeste Eng, Sandra Romero-Hidalgo, Patricia Ortiz-Tello, Victoria Robles, Eimear E. Kenny, Ismael Nuño-Arana and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1,000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between sub-continental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.