Dissemin is shutting down on January 1st, 2025

Published in

Oxford University Press (OUP), Bioinformatics, 1(29), p. 132-134

DOI: 10.1093/bioinformatics/bts656

Links

Tools

Export citation

Search in Google Scholar

DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data

Journal article published in 2012 by Clare Pacini, Francesco Iorio, Emanuel Gonçalves, Murat Iskar ORCID, Thomas Klabunde, Peer Bork ORCID, Julio Saez-Rodriguez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Summary: Drug versus Disease (DvD) provides a pipeline, available through R or Cytoscape, for the comparison of drug and disease gene expression profiles from public microarray repositories. Negatively correlated profiles can be used to generate hypotheses of drug-repurposing, whereas positively correlated profiles may be used to infer side effects of drugs. DvD allows users to compare drug and disease signatures with dynamic access to databases Array Express, Gene Expression Omnibus and data from the Connectivity Map.