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Hindawi, Case Reports in Rheumatology, (2012), p. 1-2, 2012

DOI: 10.1155/2012/517424

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Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient

Journal article published in 2012 by J. H. Izquierdo, F. Bonilla-Abadía ORCID, C. D. Ochoa, A. Agualimpia ORCID, G. J. Tobón ORCID, C. A. Cañas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report a female patient with rheumatoid arthritis which was refractory to methotrexate, leflunomide, and anti-TNF therapy. She was treated with anti-IL-6 tocilizumab (TCZ), with an early appearance of sterile pustules on erythematous swollen skin of trunk, back, and abdominal area. The lesions were consistent with the diagnosis of acute drug-related generalized exanthematous pustulosis (AGEP). This adverse event was controlled with medical treatment without requiring removal of TCZ.