Published in

BioMed Central, BMC Genomics, 1(16), 2015

DOI: 10.1186/s12864-015-1715-x

Links

Tools

Export citation

Search in Google Scholar

Runs of homozygosity and distribution of functional variants in the cattle genome

Journal article published in 2015 by Qianqian Zhang, Bernt Guldbrandtsen, Mirte Bosse ORCID, Mogens Sand Lund, Goutam Sahana
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Runs of homozygosity (ROH) are identified in four dairy cattle breeds using NGS data. Cattle populations have been exposed to strong artificial selection for some generations. Genomic regions under selection will show increased levels of ROH. By investigating the relationship between ROH and distribution of predicted deleterious and tolerated variants, we can gain insight into how selection shapes the distribution of functional variants in inbred regions. We observe that predicted deleterious variants are more enriched in ROHs than predicted tolerated variants. Moreover, increase of enrichment of deleterious variants is significantly more pronounced in short and medium ROH regions than long ROH regions (p