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British Institute of Radiology, BJR Case Reports, 3(5), p. 20190003, 2019

DOI: 10.1259/bjrcr.20190003

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First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma

Journal article published in 2019 by Maxine Tran, Arash Latifoltojar, Joana B. Neves, Marianthi-Vasiliki Papoutsaki, Fiona Gong, Arnaud Comment, Ana S. H. Costa ORCID, Matthias Glaser, My-Anh Tran-Dang, Soha El Sheikh, Wivijin Piga, Alan Bainbridge, Anna Barnes, Tim Young, Hassan Jeraj and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogation of renal cell carcinoma using hyperpolarized carbon-13 (13C) MRI and describe the validation of in vivo lactate metabolic heterogeneity against multi regional ex vivo mass spectrometry. hyperpolarized carbon-13 (13C)-MRI provides an in vivo assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity.