Published in
Public Library of Science, PLoS ONE, 11(8), p. e80588, 2013
DOI: 10.1371/journal.pone.0080588
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Diet Induced Mild Hypercholesterolemia in Pigs: Local and Systemic Inflammation, Effects on Vascular Injury – Rescue by High-Dose Statin Treatment
Journal article published in 2013 by
Marco Busnelli,
Stefano Manzini,
Alberto Froio,
Alessia Vargiolu,
Maria Grazia Cerrito 
,
Ryszard T. Smolenski,
Massimo Giunti,
Alessandro Cinti,
Augusta Zannoni,
Biagio Eugenio Leone,
Monica Forni,
Maria Laura Bacci,
Giorgio Maria Biasi,
Roberto Giovannoni ,
Marialuisa Lavitrano
,
Ryszard T. Smolenski,
Massimo Giunti,
Alessandro Cinti,
Augusta Zannoni,
Biagio Eugenio Leone,
Monica Forni,
Maria Laura Bacci,
Giorgio Maria Biasi,
Roberto Giovannoni ,
Marialuisa Lavitrano
This paper is made freely available by the publisher.
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Abstract
The aim of the present study was to comprehensively evaluate systemic and local inflammation as well as progression of vascular inflammation in normal and mechanically injured vessels in a large animal model of mild hypercholesterolemia. Our aim was also to test the effect of high-dose statin treatment on these processes.