Dissemin is shutting down on January 1st, 2025

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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(52), p. 2644-2646, 2008

DOI: 10.1128/aac.01618-07

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Impact of Mycophenolic Acid on the Functionality of Human Polymorphonuclear Neutrophils and Dendritic Cells during Interaction with Aspergillus fumigatus

Journal article published in 2008 by Markus Mezger ORCID, Iwona Wozniok, Christian Blockhaus, Oliver Kurzai ORCID, Holger Hebart, Hermann Einsele, Juergen Loeffler
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus -induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.