Published in
Royal Society of Chemistry, Chemical Science, 31(10), p. 7358-7364, 2019
DOI: 10.1039/c9sc01473j
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Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity
Journal article published in 2019 by
Robert R. A. Freund 
,
Philipp Gobrecht,
Zhigang Rao ,
Jana Gerstmeier,
Robin Schlosser,
Helmar Görls,
Oliver Werz,
Dietmar Fischer ,
Hans-Dieter Arndt
,
Philipp Gobrecht,
Zhigang Rao ,
Jana Gerstmeier,
Robin Schlosser,
Helmar Görls,
Oliver Werz,
Dietmar Fischer ,
Hans-Dieter Arndt
This paper is made freely available by the publisher.
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Abstract
The discovery of novel allylboration reagents enabled to the stereoselective synthesis of parthenolides. Biological screening for microtubule detyrosination and nerve growth promotion revealed protein target selectivity.