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National Institute of Environmental Health Sciences (NIEHS), Environmental Health Perspectives, 10(122), p. 1103-1109, 2014

DOI: 10.1289/ehp.1307044

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Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study

Journal article published in 2014 by Janie F. Shelton, Estella Marie Geraghty, Daniel J. Tancredi, Lora D. Delwiche, Rebecca J. Schmidt ORCID, Beate Ritz, Robin L. Hansen, Irva Hertz-Picciotto
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Results: Approximately one-third of CHARGE study mothers lived, during pregnancy, within 1.5 km (just under 1 mile) of an agricultural pesticide application. Proximity to organophosphates at some point during gestation was associated with a 60% increased risk for ASD, higher for thirdtrimester exposures (OR = 2.0; 95% CI: 1.1, 3.6), and second-trimester chlorpyrifos applications (OR = 3.3; 95% CI: 1.5, 7.4). Children of mothers residing near pyrethroid insecticide applications just before conception or during third trimester were at greater risk for both ASD and DD, with ORs ranging from 1.7 to 2.3. Risk for DD was increased in those near carbamate applications, but no specific vulnerable period was identified.