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Nature Research, Nature Reviews Cancer, 10(8), p. 799-806, 2008

DOI: 10.1038/nrc2500

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Replication Licensing and Cancer - a Fatal Entanglement?

Journal article published in 2008 by J. Julian Blow ORCID, J. Julian Blow, Peter J. Gillespie
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.