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American Society for Microbiology, Journal of Clinical Microbiology, 8(57), 2019

DOI: 10.1128/jcm.00415-19

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Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic Mycobacterium tuberculosis Infection and Predominance of Lineage 4

Journal article published in 2019 by L. M. van Leeuwen, P. Versteegen, S. D. Zaharie, S. L. van Elsland, A. Jordaan, E. M. Streicher ORCID, R. M. Warren, M. van der Kuip, A. M. van Furth
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Tuberculous meningitis (TBM), the most severe extrapulmonary manifestation of tuberculosis, is caused by the pathogen Mycobacterium tuberculosis . The M. tuberculosis complex includes seven lineages, all described to harbor a unique geographical dissemination pattern and clinical presentation. In this study, we set out to determine whether a certain M. tuberculosis lineage demonstrated tropism to cause TBM in patients from Cape Town, South Africa.