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Wiley, FEBS Letters, 17(586), p. 2711-2716, 2012

DOI: 10.1016/j.febslet.2012.05.005

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BRCT Domains: a little more than kin, and less than kind

Journal article published in 2012 by Dietlind L. Gerloff, Nicholas T. Woods, April A. Farago, Alvaro N. A. Monteiro ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than twenty different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.