Published in
Wiley, Journal of the American Geriatrics Society, 1(57), p. 89-93, 2009
DOI: 10.1111/j.1532-5415.2008.02080.x
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- [citeseerx.ist.psu.edu] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study
,
Marcello Maggio,
Gian Paolo Ceda,
Ceda Gp,
Simonetta Morganti,
Elisa Usberti,
Carlo Chezzi,
Rita Valcavi,
Stefania Bandinelli,
Jack M. Guralnik,
Guralnik Jm,
Cappola Ar,
Anne R. Cappola,
Giorgio Valenti
and other authors.
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Abstract
OBJECTIVES: To investigate thyroid function testing abnormalities in older persons and to explore the relationship between thyroid dysfunction and cognition. DESIGN: Cross-sectional. SETTING: Community-based. PARTICIPANTS: One thousand one hundred seventy-one men and women aged 23 to 102. MEASUREMENTS: Thyroid function was evaluated by measuring plasma concentrations of thyrotropin (TSH), free thyroxine (FT4), and free triiodothyronine (FT3). Cognition was evaluated using the Mini-Mental State Examination (MMSE). Prevalence of overt and subclinical thyroid dysfunction was evaluated in different age groups ( or =65). Age trends in TSH, FT4, and FT3 were examined in euthyroid participants. The cross-sectional association between thyroid dysfunction and MMSE score was evaluated adjusting for confounders. RESULTS: Subclinical hypothyroidism and subclinical hyperthyroidism were more prevalent in older than in younger participants (subclinical hypothyroidism, 3.5% vs 0.4%, P