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Elsevier, Bioorganic and Medicinal Chemistry Letters, 22(18), p. 5867-5870, 2008

DOI: 10.1016/j.bmcl.2008.07.068

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Synthesis and characterization of BODIPY-labeled colchicine

Journal article published in 2008 by Leggy A. Arnold, Patricia Ranaivo, R. Kiplin Guy ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Two BODIPY-labeled colchicine derivatives were synthesized and shown to bind to tubulin but only partially inhibit tubulin polymerization in the presence of GTP. Cytotoxicity studies were carried out in HeLa, HepG2, Raji and Vero cells. Apoptosis-inducing properties were determined by caspase 3/7 activity and flow cytometry and interactions between the derivatives and tubulin were verified by fluorescence microscopy of living cells.